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On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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Pentapharm pefabloc
On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), <t>Pioglitazone</t> (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.
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Image Search Results


On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), Pioglitazone (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.

Journal: bioRxiv

Article Title: One-to-one Benefit provided by Antioxidants to cultured skin Fibroblasts from Friedreich Ataxia patients

doi: 10.1101/2024.04.25.591088

Figure Lengend Snippet: On the left, the potential consequences of Frataxin gene expansion, in the middle the oxidative stress cascade, on the right, in green, the action sites of Uridine (URD), Pioglitazone (PIO) and Pyruvate (PYR) on the oxidative stress cascade. PIP 5 K 1 β, phosphatidylinositol-4-phosphate 5-kinase type 1 β; ERK1/2, extracellular signal-regulated kinase 1/2 cascade; DJ-1, a glyoxalase ) also known as Parkinson protein 7 (Park7); Nrf 2 , nuclear factor (erythroid-derived 2)-like 2; SOD, superoxide dismutase.

Article Snippet: After allowing the culture to stand for one night, the medium was changed to the desired conditions, i.e., CM medium, SC medium, or SCU, SCP, SCUP, SC or SCU plus DMSO (0.1 %) or 10 µM Pioglitazone in DMSO (Pioglitazone hydrochloride, Sigma, France).

Techniques: Derivative Assay

In the two grey boxes, representative sets of data (obtained with FRDA2 and 3 fibroblasts) illustrate the total inefficiency of Pioglitazone to rescue growth of FRDA fibroblasts. Similar inefficiency was observed in the presence of Uridine for the five FRDA cells (FRDA1-5). Notice that added Pioglitazone was resuspended in DMSO. DMSO (0.001% final) was similar under the three conditions compared. Color code as described in legend. ns , non-significant.

Journal: bioRxiv

Article Title: One-to-one Benefit provided by Antioxidants to cultured skin Fibroblasts from Friedreich Ataxia patients

doi: 10.1101/2024.04.25.591088

Figure Lengend Snippet: In the two grey boxes, representative sets of data (obtained with FRDA2 and 3 fibroblasts) illustrate the total inefficiency of Pioglitazone to rescue growth of FRDA fibroblasts. Similar inefficiency was observed in the presence of Uridine for the five FRDA cells (FRDA1-5). Notice that added Pioglitazone was resuspended in DMSO. DMSO (0.001% final) was similar under the three conditions compared. Color code as described in legend. ns , non-significant.

Article Snippet: After allowing the culture to stand for one night, the medium was changed to the desired conditions, i.e., CM medium, SC medium, or SCU, SCP, SCUP, SC or SCU plus DMSO (0.1 %) or 10 µM Pioglitazone in DMSO (Pioglitazone hydrochloride, Sigma, France).

Techniques: